Chemoenzymatic and Template-Directed Synthesis of Bioactive Macrocyclic Peptides
نویسندگان
چکیده
منابع مشابه
Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides.
Non-ribosomally synthesized peptides have compelling biological activities ranging from antimicrobial to immunosuppressive and from cytostatic to antitumor. The broad spectrum of applications in modern medicine is reflected in the great structural diversity of these natural products. They contain unique building blocks, such as d-amino acids, fatty acids, sugar moieties, and heterocyclic elemen...
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ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اول1 Bioactive Macrocyclic Peptides and Peptide Mimics
The number of both naturally occurring and synthesized biologically active cyclic peptides, modified peptides, and peptide mimics is rapidly increasing. So far, many of these sometimes biologically very potent peptides have unfortunately unknown molecular targets or mechanisms of action. This certainly opens up very interesting and challenging research areas with respect to uncovering these tar...
متن کاملTemplate-directed ligation of peptides to oligonucleotides.
BACKGROUND Oligonucleotide-peptide conjugates have several applications, including their potential use as therapeutic agents. We developed a strategy for the chemical ligation of unprotected peptides to oligonucleotides in aqueous solution. The two compounds are joined via a stable amide bond in a template-directed reaction. RESULTS Peptides, ending in a carboxy-terminal thioester, were conve...
متن کاملTemplate-constrained macrocyclic peptides prepared from native, unprotected precursors.
Peptide-protein interactions are important mediators of cellular-signaling events. Consensus binding motifs (also known as short linear motifs) within these contacts underpin molecular recognition, yet have poor pharmacological properties as discrete species. Here, we present methods to transform intact peptides into stable, templated macrocycles. Two simple steps install the template. The key ...
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ژورنال
عنوان ژورنال: Microbiology and Molecular Biology Reviews
سال: 2006
ISSN: 1092-2172,1098-5557
DOI: 10.1128/mmbr.70.1.121-146.2006